Tetrahedron letters

A new high yield semisynthetic approach to (20s)-9-NH 2-camptothecin based on a sequence of palladium-catalysed reductions

W Cabri, I Candiani, F Zarini, S Penco, A Bedeschi

Index: Cabri, Walter; Candiani, Ilaria; Zarini, Franco; Penco, Sergio; Bedeschi, Angelo Tetrahedron Letters, 1995 , vol. 36, # 50 p. 9197 - 9200

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Citation Number: 16

Abstract

A new 5-step synthesis of 9-NH2-Camptothecin starting from naturalCamptothecin is described. The approach, centred on a double palladium catalysed reduction of an arylsulfonate and a nitro group, has an overall yield consistently higher than the previously reported ones.