Scandinavian Journal of Immunology 2014-04-01

Quinoline-3-carboxamides modulate primary T cell-dependent B cell responses but do not inhibit functional immunity.

E Källberg, F Ivars, T Leanderson

Index: Scand. J. Immunol. 79(4) , 237-43, (2014)

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Abstract

The effect of a quinoline-3-carboxamide on the T cell-dependent B cell response was investigated in C57BL/6 mice after NP-CGG immunization. The primary serum response to the hapten was slightly inhibited by treatment with a quinoline-3-carboxamide. This inhibition was paralleled by reduced numbers of germinal centre (GC) B cells and follicular T cells in the spleen up to 21 days after immunization. Also, both the number of GCs formed and their size were reduced by quinoline-3-carboxamide treatment. In contrast to the observation in the primary immune response, there was no inhibitory effect on the secondary immune response. These data could help to explain how quinoline-3-carboxamides can modulate immune function in autoimmune diseases without being immunosuppressive.© 2014 John Wiley & Sons Ltd.

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