Drug Design, Development and Therapy 2015-01-01

Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats.

Chien-Min Lin, Jo-Ting Tsai, Chen Kuei Chang, Juei-Tang Cheng, Jia-Wei Lin

Index: Drug Des. Devel. Ther. 9 , 4709-17, (2015)

Full Text: HTML

Abstract

Decrease of peroxisome proliferator-activated receptors-δ (PPARδ) expression has been observed after spinal cord injury (SCI). Increase of PPARδ may improve the damage in SCI. Telmisartan, the antihypertensive agent, has been mentioned to increase the expression of PPARδ. Thus, we are going to screen the effectiveness of telmisartan in SCI for the development of it in clinical application.In the present study, we used compressive SCI in rats. Telmisartan was then used to evaluate the influence in rats after SCI. Change in PPARδ expression was identified by Western blots. Also, behavioral tests were performed to check the recovery of damage.Recovery of damage from SCI was observed in telmisartan-treated rats. Additionally, this action of telmisartan was inhibited by GSK0660 at the dose sufficient to block PPARδ. However, metformin at the dose enough to activate adenosine monophosphate-activated protein kinase failed to produce similar action as telmisartan. Thus, mediation of adenosine monophosphate-activated protein kinase in this action of telmisartan can be rule out. Moreover, telmisartan reversed the expressions of PPARδ in rats with SCI.The obtained data suggest that telmisartan can improve the damage of SCI in rats through an increase in PPARδ expression. Thus, telmisartan is useful to be developed as an agent in the therapy of SCI.

Related Compounds

  • Dimethyl sulfoxide
  • GSK0660
  • Telmisartan

Related Articles:

The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells.

2015-01-01

[Drug Des. Devel. Ther. 9 , 1627-52, (2015)]

Activation of Tomato Bushy Stunt Virus RNA-Dependent RNA Polymerase by Cellular Heat Shock Protein 70 Is Enhanced by Phospholipids In Vitro.

2015-05-01

[J. Virol. 89(10) , 5714-23, (2015)]

Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis.

2015-01-01

[EMBO Mol. Med. 7(1) , 102-23, (2015)]

Inducible, tightly regulated and growth condition-independent transcription factor in Saccharomyces cerevisiae.

2014-01-01

[Nucleic Acids Res. 42(17) , e130, (2014)]

Co-ordinated brain and craniofacial development depend upon Patched1/XIAP regulation of cell survival.

2015-02-01

[Hum. Mol. Genet. 24(3) , 698-713, (2015)]

More Articles...