Antihypertensive 5, 6-diarylpyridazin-3-ones

R Buchman, JA Scozzie, ZS Ariyan…

Index: Buchman; Scozzie; Ariyan; Heilman; Rippin; Pyne; Powers; Matthews Journal of Medicinal Chemistry, 1980 , vol. 23, # 12 p. 1398 - 1405

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Citation Number: 16

Abstract

The synthesis of a series of 5, 6-diarylpyridazinones is described, Some members of this series display an antihypertensive effect in both the spontaneously hypertensive rat (SHR) model and the deoxycorticosteroid@ OCA) model of hypertension. The most potent compounds in the series have halogen substituents on the 5, 6-diphenyl rings, a 0- substituted alkyl group at the 2 position of the ring, and an acetyl or cyano substituent at ...