Palladium-catalysed aminosulfonylation of aryl-, alkenyl-and heteroaryl halides: scope of the three-component synthesis of N-aminosulfonamides

EJ Emmett, CS Richards-Taylor, B Nguyen…

Index: Emmett, Edward J.; Richards-Taylor, Charlotte S.; Nguyen, Bao; Garcia-Rubia, Alfonso; Hayter, Barry R.; Willis, Michael C. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 20 p. 4007 - 4014

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Citation Number: 47

Abstract

By using DABCO·(SO2) 2, DABSO, as a solid bench-stable SO2-equivalent, the palladium- catalysed aminosulfonylation of aryl-, alkenyl-and heteroaryl halides has been achieved. N, N-Dialkylhydrazines are employed as the N-nucleophiles and provide N- aminosulfonamides as the products in good to excellent yields. The reactions are operationally simple to perform, requiring only a slight excess of SO2 (1.2–2.2 equiv.), and ...

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