Nature Chemical Biology 2010-09-01

A copper-containing oxidase catalyzes C-nitrosation in nitrosobenzamide biosynthesis.

Akio Noguchi, Takeshi Kitamura, Hiroyasu Onaka, Sueharu Horinouchi, Yasuo Ohnishi

Index: Nat. Chem. Biol. 6(9) , 641-3, (2010)

Full Text: HTML

Abstract

Although C-nitroso aromatic compounds have several bioactivities of medicinal interest, the biosynthetic enzymes involved in C-nitrosation have remained unknown until now. Here, we report the entire biosynthesis pathway of 4-hydroxy-3-nitrosobenzamide in Streptomyces murayamaensis, in which a tyrosinase-like copper-containing monooxygenase is responsible for the C-nitrosation. This finding indicates diverse catalytic functions of tyrosinase-like copper-containing monooxygenases in nature.

Related Compounds

  • 3-nitrosobenzamide

Related Articles:

The site of antiviral action of 3-nitrosobenzamide on the infectivity process of human immunodeficiency virus in human lymphocytes.

1993-10-15

[Proc. Natl. Acad. Sci. U. S. A. 90 , 9721, (1993)]

Inhibition of the replication of native and 3'-azido-2',3'-dideoxythymidine (AZT)-resistant simian immunodeficiency virus (SIV) by 3-nitrosobenzamide.

1993-07-12

[FEBS Lett. 326 , 140, (1993)]

Structure/function correlations among coupled binuclear copper proteins through spectroscopic and reactivity studies of NspF.

2012-07-03

[Proc. Natl. Acad. Sci. U. S. A. 109(27) , 10793-7, (2012)]

Anti-HIV agents that selectively target retroviral nucleocapsid protein zinc fingers without affecting cellular zinc finger proteins.

1998-04-23

[J. Med. Chem. 41(9) , 1371-81, (1998)]

Inhibition of HIV-1 infectivity by zinc-ejecting aromatic C-nitroso compounds.

1993-02-04

[Nature 361 , 473, (1993)]

More Articles...