Mini-Reviews in Medicinal Chemistry 2010-06-01

Specificity in the interaction of natural products with their target proteins--a biochemical and structural insight.

Prasanna Venkatraman

Index: Mini Rev. Med. Chem. 10(6) , 540-9, (2010)

Full Text: HTML

Abstract

Natural products are an abundant source of anti cancer agents. They act as cytotoxic drugs, and inhibitors of apoptosis, transcription, cell proliferation and angiogenesis. While pathways targeted by natural products have been well studied, there is paucity of information about the in vivo molecular target/s of these compounds. This review summarizes some of the natural compounds for which the molecular targets, mechanism of action and structural basis of specificity have been well documented. These examples illustrate that 'off target' binding can be explained on the basis of diversity inherent to biomolecular interactions. There is enough evidence to suggest that natural compounds are potent and versatile warheads that can be optimized for a multi targeted therapeutic intervention in cancer.

Related Compounds

  • fumagillin

Related Articles:

Fumagillin prodrug nanotherapy suppresses macrophage inflammatory response via endothelial nitric oxide.

2014-07-22

[ACS Nano 8(7) , 7305-17, (2014)]

Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats.

2012-01-01

[PLoS ONE 7(4) , e35388, (2012)]

The Aspergillus fumigatus toxin fumagillin suppresses the immune response of Galleria mellonella larvae by inhibiting the action of haemocytes.

2011-05-01

[Microbiology 157(Pt 5) , 1481-8, (2011)]

Methionine aminopeptidase 2 is required for HSC initiation and proliferation.

2011-11-17

[Blood 118(20) , 5448-57, (2011)]

Rapid determination of fumagillin residues in honey by liquid chromatography-tandem mass spectrometry using the QuEChERS method.

2011-01-01

[J. AOAC Int. 94(3) , 878-85, (2011)]

More Articles...