Journal of heterocyclic chemistry

Studies on pyrazines. 14 The syntheses of 2, 5??dihydroxypyrazines and their derivatives

J Adachi, N Sato

Index: Adachi, Jiro; Sato, Nobuhiro Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 3 p. 871 - 875

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Citation Number: 8

Abstract

Abstract Reaction of phenylglycinamide (1c) with ethyl benzoylformate (2c) in the presence of refluxing ethanolic sodium ethoxide gave 2, 5-dihydroxy-3, 6-diphenylpyrazine (3i) in 19% yield. This synthetic method, however, was limited to the preparation of 3i. On the other hand, α-aminoamides 1 condensed with α-ketoesters 2 to give the intermediates 5, which were also prepared by condensation of 1 with α-ketalesters 6, followed by hydrolysis of ...

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