Mercapturic acid metabolites from 2-, 3-, and 4-ethenyl-methylbenzenes in the rat.
T Kühler
Index: Xenobiotica 14(5) , 417-28, (1984)
Full Text: HTML
Abstract
N-Acetyl-L-cysteine was reacted with 2-(2-, 3-, or 4-methylphenyl)-oxiranes to give mixtures of the two possible regio isomers N-acetyl-S-[1-(2-, 3-, or 4-methylphenyl)-2-hydroxyethyl]-L-cysteine and N-acetyl-S-[2-(2-, 3-, or 4-methylphenyl)-2-hydroxyethyl]-L-cysteine, respectively. These were isolated in pure form by h.p.l.c.. The diastereomers were characterized by n.m.r. and mass spectrometry. The 2-, 3- and 4-ethenyl-methylbenzenes and the 2-(2-, 3-, and 4-methylphenyl)-oxiranes were injected i.p. into rats. G.l.c.-mass spectrometry showed similar patterns of acidic metabolites in the urine. Comparison with authentic mass spectra showed that the N-acetyl-S-[1-(methylphenyl)-2-hydroxyethyl]-L-cysteines accounted for over 80% of the mercapturic acids.
Related Compounds
Related Articles:
2013-06-17
[Chemistry 19(25) , 8276-84, (2013)]
2006-04-14
[J. Chem. Phys. 124(14) , 144316, (2006)]
Syndiospecific living polymerization of 4-methylstyrene and styrene with (trimethyl) pentamethylcyclopentadienyltitanium/tris (pentafluorophenyl) borane/trioctylaluminum catalytic system. Kawabe M and Murata M.
[J. Polym. Sci. A Polym. Chem. 39(21) , 3692-3706, (2001)]
An efficient palladium-catalyzed Heck coupling of aryl chlorides with alkenes. Yi C and Hua R.
[Tetrahedron Lett. 47(15) , 2573-76, (2006)]