China Journal of Chinese Materia Medica 2011-04-01

[Pharmacokinetics of Guizhi Fuling capsule in Beagle dogs].

Kejin Zhu, Xiaoping Sun, Xiujuan Chang, Jianping Qin, Xinyong Lv, Zhenzhong Wang, Wei Xiao

Index: Zhongguo Zhong Yao Za Zhi 36(8) , 1015-8, (2011)

Full Text: HTML

Abstract

To investigate pharmacokinetic parameters of peoniflorin, albiflorin and amygdaloside after administration of Guizhi Fuling capsule in beagle dogs.Plasma was collected from forelimb vein of Beagle dogs after oral administration of Guizhi Fuling capsule. HPLC-MS/MS method was used to determine the concentrations of constituents in plasma. The pharmacokinetic parameters were analyzed by program DAS 2.0.The limit of quantitation of peoniflorin, albiflorin and amygdaloside were 0.25, 2.64, 0.04 microg x L(-1), respectively. After administrated with different doses, half-life of peoniflorin in dogs were 4.33, 3.62 h, albiflorin were 6.16, 5.91 h, amygdaloside were 2.43, 1.32 h. The AUC(0-t) of all components were related to dose.The pharmacokinetic course of peoniflorin, albiflorin and amygdaloside can be described by two-compartment model, and these components have high expose.

Related Compounds

  • albiflorin
  • Amygdalin

Related Articles:

Anti-adipogenic and antioxidant effects of the traditional Korean herbal formula Samchulgeonbi-tang: an in vitro study.

2015-01-01

[Int. J. Clin. Exp. Med. 8 , 8698-708, (2015)]

Anti-inflammatory actions of herbal formula Gyejibokryeong-hwan regulated by inhibiting chemokine production and STAT1 activation in HaCaT cells.

2015-01-01

[Biol. Pharm. Bull. 38(3) , 425-34, (2015)]

Detection of paeoniflorin and albiflorin by immunostaining technique using anti-paeoniflorin monoclonal antibody.

2013-02-01

[Phytochem. Anal. 24(2) , 124-8, (2013)]

Development of validated determination of the eleven marker compounds in Gyejibokryeong-hwan for the quality assessment using HPLC analysis.

2015-01-01

[Arch. Pharm. Res. 38(1) , 52-62, (2015)]

Inhibitory activity of Socheongryong‑tang and its constituent components against the production of RANTES, eotaxin, eotaxin‑3 and MMP‑9 from BEAS‑2B cells.

2014-12-01

[Mol. Med. Report. 10(6) , 3035-46, (2014)]

More Articles...