Palladium-Catalyzed Annulation of Arynes by o-Halobenzamides: Synthesis of Phenanthridinones

C Lu, AV Dubrovskiy, RC Larock

Index: Lu, Chun; Dubrovskiy, Anton V.; Larock, Richard C. Journal of Organic Chemistry, 2012 , vol. 77, # 19 p. 8648 - 8656

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Citation Number: 21

Abstract

The palladium-catalyzed annulation of arynes by substituted o-halobenzamides produces N- substituted phenanthridinones in good yields. This methodology provides this important heterocyclic ring system in a single step by simultaneous C–C and C–N bond formation, under relatively mild reaction conditions, and tolerates a variety of functional groups.

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