Chemical Communications 2013-04-25

Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity.

Wolfgang Kandioller, Evelyn Balsano, Samuel M Meier, Ute Jungwirth, Simone Göschl, Alexander Roller, Michael A Jakupec, Walter Berger, Bernhard K Keppler, Christian G Hartinger

Index: Chem. Commun. (Camb.) 49(32) , 3348-50, (2013)

Full Text: HTML

Abstract

Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

Related Compounds

  • Rhodium
  • Ruthenium
  • Osmium
  • Lapachol
  • 9-ethylguanine

Related Articles:

Toxic impact of bromide and iodide on drinking water disinfected with chlorine or chloramines.

2014-10-21

[Environ. Sci. Technol. 48(20) , 12362-9, (2014)]

Synthesis and Temperature-Induced Structural Phase and Spin Transitions in Hexadecylboron-Capped Cobalt(II) Hexachloroclathrochelate and Its Diamagnetic Iron(II)-Encapsulating Analogue.

2015-06-15

[Inorg. Chem. 54 , 5827-38, (2015)]

Bio-inspired catalytic imine reduction by rhodium complexes with tethered Hantzsch pyridinium groups: evidence for direct hydride transfer from dihydropyridine to metal-activated substrate.

2013-03-18

[Angew. Chem. Int. Ed. Engl. 52(12) , 3411-6, (2013)]

Lead exposure causes thyroid abnormalities in diabetic rats.

2015-01-01

[Int. J. Clin. Exp. Med. 8 , 7160-7, (2015)]

Gravimetric preparation and characterization of primary reference solutions of molybdenum and rhodium.

2015-04-01

[Anal. Bioanal. Chem 407(11) , 3093-102, (2015)]

More Articles...