Bioorganic & Medicinal Chemistry Letters 2012-01-01

Synthesis and antihyperglycemic evaluation of new 2,4-thiazolidinediones having biodynamic aryl sulfonylurea moieties.

Dhanaji V Jawale, Umesh R Pratap, Neha Rahuja, Arvind K Srivastava, Ramrao A Mane

Index: Bioorg. Med. Chem. Lett. 22(1) , 436-9, (2012)

Full Text: HTML

Abstract

New 2,4-thiazolidinediones with aryl sulfonylurea moieties have been synthesized by condensing various substituted sulfonamides and 5-(isocyanatomethyl) thiazolidino-2,4-dione. The isocyanomethyl thiazolidinedione was obtained by using the Curtius rearrangement, starting from known 2,4-dioxo-5-thiazolidineacetic acid. The newly synthesized compounds have been evaluated for the antihyperglycemic activity in normal rats model and among these compounds showed significant antihyperglycemic activity in sucrose loaded rat model.Copyright © 2011 Elsevier Ltd. All rights reserved.

Related Compounds

  • 2,4-Thiazolidinedi...

Related Articles:

Cytotoxicity of thiazolidinedione-, oxazolidinedione- and pyrrolidinedione-ring containing compounds in HepG2 cells.

2015-10-01

[Toxicol. In Vitro 29 , 1887-96, (2015)]

Differential cardiovascular outcomes after dipeptidyl peptidase-4 inhibitor, sulfonylurea, and pioglitazone therapy, all in combination with metformin, for type 2 diabetes: a population-based cohort study.

2015-01-01

[PLoS ONE 10 , e0124287, (2015)]

Effects of Various 5,7-Dihydroxyflavone Analogs on Adipogenesis in 3T3-L1 Cells.

2015-01-01

[Biol. Pharm. Bull. 38 , 1794-800, (2015)]

The novel benzimidazole derivative BRP-7 inhibits leukotriene biosynthesis in vitro and in vivo by targeting 5-lipoxygenase-activating protein (FLAP).

2014-06-01

[Br. J. Pharmacol. 171(12) , 3051-64, (2014)]

SAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors.

2005-11-17

[J. Med. Chem. 48 , 7103-12, (2005)]

More Articles...