Reaction of 2, 4-dibromoquinoline with Hydrogen chloride

VP Andreev, YP Nizhnik

Index: Andreev; Nizhnik Russian Journal of Organic Chemistry, 2002 , vol. 38, # 1 p. 137 - 138

Full Text: HTML

Citation Number: 2

Abstract

It is known that nucleophilic aromatic substitution in nitrogen-containing heterocycles by the action of such weak nucleophiles as halide ions is very difficult to occur, even when the heteroring is activated by N-oxide moiety. For example, replacement of nitro group in heteroaromatic N-oxides requires severe conditions: heating with concentrated hydrohalic acids at the boiling boint or using acetyl or phosphinoyl halides [1]. According to the recent ...