Eksperimental'naia i klinicheskaia farmakologiia 2011-01-01

[Effect of migrepin on activity of trigeminal nucleus caudalis neurons].

A Iu Sokolov, O A Liubashina, Iu D Ignatov, S S Panteleev, A O Syrovaia, T V Zviagintseva

Index: Eksp. Klin. Farmakol. 74(5) , 13-6, (2011)

Full Text: HTML

Abstract

Neurophysiological experiments on anesthetized rats were used to study the effects of various doses (12.5, 25, 37.5 mg/kg, i.v.) of drug composition migrepin (representing a combination of potassium-2,4-dichlorobenzoate, carbamazepine, and caffeine) on background firing of the trigeminal nucleus caudalis neurons and their responses to electrical stimulation of the dura mater. It was found that migrepin produces direct, dose-dependent inhibitory action on functional activity of TNC neurons. The results confirmed anti-migraine properties of the drug but did not exclude the necessity to study its action in clinical trials.

Related Compounds

  • 2,4-Dichlorobenzoi...

Related Articles:

Ambigol C and 2,4-dichlorobenzoic acid, natural products produced by the terrestrial cyanobacterium Fischerella ambigua.

2005-03-01

[J. Nat. Prod. 68 , 459-61, (2005)]

NADPH-dependent reductive ortho dehalogenation of 2,4-dichlorobenzoic acid in Corynebacterium sepedonicum KZ-4 and Coryneform bacterium strainNTB-1 via 2,4-dichlorobenzoyl coenzyme A.

1996-05-01

[J. Bacteriol. 178(9) , 2656-61, (1996)]

Automated dynamic liquid-liquid-liquid microextraction followed by high-performance liquid chromatography-ultraviolet detection for the determination of phenoxy acid herbicides in environmental waters.

2005-08-05

[J. Chromatogr. A. 1082(2) , 121-7, (2005)]

Genetic control of degradation of chlorinated benzoic acids in Arthrobacter globiformis, Corynebacterium sepedonicum and Pseudomonas cepacia strains.

1991-06-15

[FEMS Microbiol. Lett. 65(2) , 171-6, (1991)]

New polymeric composites based on poly(-caprolactone) and layered double hydroxides containing antimicrobial species.

2009-03-01

[ACS Appl. Mater. Interfaces 1(3) , 668-77, (2009)]

More Articles...