Antimicrobial Agents and Chemotherapy 2010-05-01

Antistaphylococcal activity of ACHN-490 tested alone and in combination with other agents by time-kill assay.

Gengrong Lin, Lois M Ednie, Peter C Appelbaum

Index: Antimicrob. Agents Chemother. 54(5) , 2258-61, (2010)

Full Text: HTML

Abstract

Synergy time-kill studies of 47 methicillin-resistant Staphylococcus aureus strains with differing resistance phenotypes showed that combinations of subinhibitory concentrations of ACHN-490 and daptomycin yielded synergy against 43/47 strains at 24 h, while the combination was indifferent against the remaining 4 strains. ACHN-490 and ceftobiprole showed synergy in 17/47 strains tested at 24 h, while 6/47 strains showed synergy for subinhibitory combinations of ACHN-490 and linezolid.

Related Compounds

  • Sisomycin Sulfate

Related Articles:

Determination of equilibrium constant of amino carbamate adduct formation in sisomicin by a high pH based high performance liquid chromatography.

2015-01-01

[J. Pharm. Biomed. Anal. 111 , 126-30, (2015)]

Biomimetic synthesis and structural refinement of the macrocyclic dimer aminoglycoside 66-40C--the remarkably selective self-condensation of a putative aldehyde intermediate in the submerged culture medium producing sisomicin.

2010-03-28

[Chem. Commun. (Camb.) 46(12) , 2013-5, (2010)]

Pharmacokinetics and safety of single and multiple doses of ACHN-490 injection administered intravenously in healthy subjects.

2011-12-01

[Antimicrob. Agents Chemother. 55(12) , 5874-80, (2011)]

Activity of ACHN-490 against meticillin-resistant Staphylococcus aureus (MRSA) isolates from patients in US hospitals.

2011-10-01

[Int. J. Antimicrob. Agents 38(4) , 352-4, (2011)]

Activity of a novel aminoglycoside, ACHN-490, against clinical isolates of Escherichia coli and Klebsiella pneumoniae from New York City.

2010-10-01

[J. Antimicrob. Chemother. 65(10) , 2123-7, (2010)]

More Articles...