Tetrahedron letters

A one-step synthesis of pseudoephedrine glycinamide, a versatile precursor for the synthesis of α-amino acids

AG Myers, T Yoon, JL Gleason

Index: Myers, Andrew G.; Yoon, Taeyoung; Gleason, James L. Tetrahedron Letters, 1995 , vol. 36, # 26 p. 4555 - 4558

Full Text: HTML

Citation Number: 39

Abstract

Both enantiomers of pseudoephedrine glycinamide [(+)-or (−)-1] were synthesized by either of two procedures:(1) a standard two-step coupling of N-Boc-Gly with pseudoephedrine followed by deprotection, or (2) a more economical one-step coupling reaction of Gly-OMe with pseudoephedrine mediated by LiCl and base.

Related Articles:

Poly (vinyl) chloride supported palladium nanoparticles: catalyst for rapid hydrogenation reactions

[Hemantha, Hosahalli P.; Sureshbabu, Vommina V. Organic and Biomolecular Chemistry, 2011 , vol. 9, # 8 p. 2597 - 2601]

Use of an Ionic Liquid as a Co-solvent for Recyclable Pd/C-mediated N-Debenzylation

[Bulletin of the Korean Chemical Society, , vol. 31, # 3 p. 735 - 738]

Hydroxylamine as an oxygen nucleophile: substitution of sulfonamide by a hydroxyl group in benzothiazole-2-sulfonamides

[Organic and Biomolecular Chemistry, , vol. 11, # 7 p. 1103 - 1108]

Ceric ammonium nitrate (CAN) mediated esterification of N-Boc amino acids allows either retention or removal of the N-Boc group

[Kuttan, Ashani; Nowshudin, Shiek; Rao Tetrahedron Letters, 2004 , vol. 45, # 12 p. 2663 - 2665]

Facile reduction of azides to the corresponding amines with metallic samarium and catalytic amount of lodine

[Huang, You; Zhang, Yongmin; Wang, Yulu Tetrahedron Letters, 1997 , vol. 38, # 6 p. 1065 - 1066]

More Articles...