Bulletin of Experimental Biology and Medicine 2013-01-01

Multidirectional effects of calmodulin kinase II on transmitter release in mature and newly formed mouse motor synapses.

P O Bogatcheva, O P Balezina

Index: Bull. Exp. Biol. Med. 154(3) , 316-9, (2013)

Full Text: HTML

Abstract

Calmodulin inhibitor W-7 did not cause changes in the quantal content of postsynaptic end-plate potentials (EPP) in newly formed synapses, but prevented facilitation of acetylcholine secretion induced by L-type Ca(2+)channels blocker nitrendipine. CaMKII inhibitor KN-62 produced similar effect and suppressed the increase in EPP quantal content caused by blockade of L-type Ca(2+)channels. Phosphatase PP2A inhibitor okadaic acid significantly facilitated secretion in newly formed synapses; the effect was completely blocked by KN-62. In mature synapses, okadaic acid had no effect on transmitter secretion. KN-62 increased EPP quantal content. We hypothesize that CaMKII produced different effects on acetylcholine secretion in mature and immature synapses depending on specificity of calcium signaling and PP2A phosphatase activity.

Related Compounds

  • Nitrendipine
  • Okadaic acid
  • W-7 hydrochloride
  • H-7
  • KN-62

Related Articles:

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

2010-01-01

[Chem. Res. Toxicol. 23 , 171-83, (2010)]

Chemical genetics reveals a complex functional ground state of neural stem cells.

2007-05-01

[Nat. Chem. Biol. 3(5) , 268-273, (2007)]

Neural computational prediction of oral drug absorption based on CODES 2D descriptors.

2010-03-01

[Eur. J. Med. Chem. 45 , 930-40, (2010)]

Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

2008-06-12

[J. Med. Chem. 51 , 3275-87, (2008)]

Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.

2009-10-01

[Bioorg. Med. Chem. 17 , 6983-92, (2009)]

More Articles...