Current Allergy & Asthma Reports 2009-03-01

Guaifenesin in rhinitis.

William Storms, Judith R Farrar

Index: Curr. Allergy Asthma Rep. 9(2) , 101-6, (2009)

Full Text: HTML

Abstract

Mucus in the airways is a complex mixture of water, lipids, glycoproteins, sugars, and electrolytes that serves as a lubricant for the epithelium. The efficient flow of respiratory mucus is a first level of immune defense that requires an appropriate viscosity and elasticity for optimal barrier and ciliary functions. Thickening and drying of airway mucus by respiratory tract infections, allergies, and drugs can impair evacuation. Tenacious, bothersome mucus is an annoying and frequent symptom of rhinitis that is difficult to manage. Common remedies include adequate hydration through fluid intake and nasal washes. The use of mucoactive agents is controversial due to limited data and equivocal efficacy in available studies. Nonetheless, some patients benefit. This review examines the use of guaifenesin (glyceryl guaiacolate) on bothersome nasal mucus associated with rhinitis, including the available published data and clinical experience.

Related Compounds

  • Guaifenesin

Related Articles:

Treatment of immune-mediated keratitis in horses with episcleral silicone matrix cyclosporine delivery devices.

2014-07-01

[Vet. Ophthalmol. 17 Suppl 1 , 23-30, (2014)]

Experiment and modeling for the separation of guaifenesin enantiomers using simulated moving bed and Varicol units.

2014-10-10

[J. Chromatogr. A. 1363 , 242-9, (2014)]

Solubility and some crystallization properties of conglomerate forming chiral drug guaifenesin in water.

2014-10-01

[J. Pharm. Sci. 103(10) , 3176-82, (2014)]

Question: does guaifenesin improve outcomes in patients with cough associated with upper respiratory infection compared with no intervention?

2012-10-01

[J. Okla. State Med. Assoc. 105(10) , 397-8, (2012)]

Case report: anaphylactic reaction to guaifenesin.

2009-12-01

[Hosp. Pract. (Minneap) 37(1) , 60-3, (2009)]

More Articles...