Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia

…, B Kang, SY Kim, HD Kim, JH Ryu, R Jeon

Index: Jin, Guo Hua; Ha, Sang Keun; Park, Hye Min; Kang, Bomi; Kim, Sun Yeou; Kim, Hee-Do; Ryu, Jae-Ha; Jeon, Raok Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 14 p. 4092 - 4094

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Citation Number: 17

Abstract

A series of azaisoflavones were synthesized and their biological activities were evaluated for nitric oxide (NO) production and inducible NO synthase (iNOS) expression in BV-2 microglia cell lines. Among these compounds, compound 8d was the most potent with IC50 7.83 μM for inhibition of NO production. Also, compound 8d inhibited expression of iNOS in LPS-induced BV2 cells. This result suggests that compound 8d inhibited the production of ...

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