Journal of Organic Chemistry 2012-09-07

Iron-catalyzed formation of 2-aminopyridines from diynes and cyanamides.

Timothy K Lane, Brendan R D'Souza, Janis Louie

Index: J. Org. Chem. 77(17) , 7555-63, (2012)

Full Text: HTML

Abstract

Diynes and cyanamides undergo an iron-catalyzed [2 + 2 + 2] cycloaddition to form highly substituted 2-aminopyridines in an atom-efficient manner that is both high yielding and regioselective. This system was also used to cyclize two terminal alkynes and a cyanamide to afford a 2,4,6-trisubstituted pyridine product regioselectively.

Related Compounds

  • 2-Aminopyridine
  • Cyanamide
  • Calcium cyanamide

Related Articles:

Determination of major sialylated N-glycans and identification of branched sialylated N-glycans that dynamically change their content during development in the mouse cerebral cortex.

2014-12-01

[Glycoconj. J. 31(9) , 671-83, (2014)]

One-pot synthesis of 2-phenylimidazo[1,2-α]pyridines from acetophenone, [Bmim]Br(3) and 2-aminopyridine under solvent-free conditions.

2012-01-01

[Molecules 17(11) , 13368-75, (2012)]

Synthesis and Characterization of a Novel Phenolic Lipid for Use as Potential Lipophilic Antioxidant and as a Prodrug of Butyric Acid.

2015-01-01

[J. Oleo Sci. 64 , 845-52, (2015)]

Aryl H-phosphonates 17: (N-aryl)phosphoramidates of pyrimidine nucleoside analogues and their synthesis, selected properties, and anti-HIV activity.

2011-10-13

[J. Med. Chem. 54 , 6482-91, (2011)]

Synthesis and characterization of binary and ternary complexes of Co(II), Ni(II), Cu(II) and Zn(II) ions based on 4-aminotoluene-3-sulfonic acid.

2013-03-15

[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 105 , 109-24, (2013)]

More Articles...