The Base-catalyzed Condensation of Aldehydes with Methyl Isopropyl Ketone1

AT Nielsen, EBW Ovist

Index: Nielsen; Ovist Journal of the American Chemical Society, 1954 , vol. 76, p. 5165

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Abstract

NOTES 5165 ketone, 6-ethyl-2-methyl-4-octen-3-one (IV), was obtained as the main product in 47% yield; the structure of IV was confirmed by ozonolysis of it to a-ethylbutyric and isobutyric acids. The ketol, 6-ethyl-5-hydroxy-2-methyl-3-octanone (111), obtained in 6.5% yield, gave a 75% yield of IV when heated with iodine (86% water of dehydration). Thus, in this case, 98% or more of the ketone condensation occurred on the methyl group. In the n- ...