Journal of Biological Chemistry 2012-09-14

Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate (NAADP) as messengers for calcium mobilization.

Hon Cheung Lee

Index: J. Biol. Chem. 287(38) , 31633-40, (2012)

Full Text: HTML

Abstract

Cyclic ADP-ribose and nicotinic acid adenine dinucleotide phosphate were discovered >2 decades ago. That they are second messengers for mobilizing Ca(2+) stores has since been firmly established. Separate stores and distinct Ca(2+) channels are targeted, with cyclic ADP-ribose acting on the ryanodine receptors in the endoplasmic reticulum, whereas nicotinic acid adenine dinucleotide phosphate mobilizes the endolysosomes via the two-pore channels. Despite the structural and functional differences, both messengers are synthesized by a ubiquitous enzyme, CD38, whose crystal structure and catalytic mechanism have now been well elucidated. How this novel signaling enzyme is regulated remains largely unknown and is the focus of this minireview.

Related Compounds

  • NAADP tetrasodiu...
  • Cyclic ADP-​rib...

Related Articles:

Involvement of actin filament in the generation of Ca2+ mobilizing messengers in glucose-induced Ca2+ signaling in pancreatic β-cells.

2012-01-01

[Islets 4(2) , 145-51, (2012)]

The N-terminal region of two-pore channel 1 regulates trafficking and activation by NAADP.

2013-07-01

[Biochem. J. 453(1) , 147-51, (2013)]

Nicotinic acid adenine dinucleotide phosphate (NAADP)-mediated calcium signaling and arrhythmias in the heart evoked by β-adrenergic stimulation.

2013-05-31

[J. Biol. Chem. 288(22) , 16017-30, (2013)]

Two-pore channels function in calcium regulation in sea star oocytes and embryos.

2014-12-01

[Development 141(23) , 4598-609, (2014)]

N-terminal tagging of two-pore channels interferes with NAADP action.

2013-07-01

[Biochem. J. 453(1) , e1-2, (2013)]

More Articles...