FEBS Letters 2014-08-25

Exploring the anti-apoptotic role of HAX-1 versus BCL-XL in cytokine-dependent bone marrow-derived cells from mice.

Alicja Trebinska, Kari Högstrand, Alf Grandien, Ewa A Grzybowska, Bengt Fadeel

Index: FEBS Lett. 588(17) , 2921-7, (2014)

Full Text: HTML

Abstract

HS-1-associated protein X-1 (HAX-1) is a multi-functional protein that has been implicated in the regulation of apoptosis, cell motility and calcium homeostasis. In the present study, we set out to assess the postulated functional resemblance of HAX-1 to the BCL-2 family of anti-apoptotic proteins using non-transformed, cytokine-dependent murine bone marrow cells as a model system. BCL-X(L), but not HAX-1 protected against cytokine withdrawal-induced apoptosis while HAX-1 and BCL-X(L) significantly reduced thapsigargin-triggered (calcium-dependent) apoptosis. The data argue in favor of cell type- and stimulus-specific roles of HAX-1 in regulation of cell survival.Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Related Compounds

  • L-Glutamine
  • HEPES
  • Thapsigargin
  • Orbifloxacin

Related Articles:

ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.

2015-01-01

[Nat. Commun. 6 , 5794, (2015)]

Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy.

2015-05-01

[Biomaterials 51 , 1-11, (2015)]

25-O-acetyl-23,24-dihydro-cucurbitacin F induces cell cycle G2/M arrest and apoptosis in human soft tissue sarcoma cells.

2015-04-22

[J. Ethnopharmacol. 164 , 265-72, (2015)]

Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.

2015-01-01

[Drug Des. Devel. Ther. 9 , 1555-84, (2015)]

SPREDs (Sprouty related proteins with EVH1 domain) promote self-renewal and inhibit mesodermal differentiation in murine embryonic stem cells.

2015-04-01

[Dev. Dyn. 244(4) , 591-606, (2015)]

More Articles...