Direct, Enantioselective Iridium??Catalyzed Allylic Amination of Racemic Allylic Alcohols

M Lafrance, M Roggen…

Index: Lafrance, Marc; Roggen, Markus; Carreira, Erick M. Angewandte Chemie - International Edition, 2012 , vol. 51, # 14 p. 3470 - 3473

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Citation Number: 68

Abstract

Transition-metal-catalyzed asymmetric allylic substitution reactions constitute one of the most convenient approaches for the generation of optically active allylic amines.[1] The best solutions for the enantioselective synthesis of optically active amines from precursor allylic alcohols to date involve the use of primary allylic esters,[2a, b] carbonates,[2c–l] and phosphates [2m] as substrates. Substitution of a racemic mixture of secondary allylic ...