Brain Research 2004-05-15

Effect of NaCN on currents evoked by uremic retention solutes in dissociated mouse neurons.

A Torremans, R D'Hooge, G Van de Vijver, B Marescau, R Vanholder, N Lameire, P P De Deyn, P P Van Bogaert

Index: Brain Res. 1008(1) , 107-12, (2004)

Full Text: HTML

Abstract

Uremic retention solutes possibly contribute to neuronal hypoxia/ischemia and its consequences in patients with renal failure. We examined the in vitro effects of several uremic retention solutes on murine central neurons under chemically induced metabolic hypoxia by application of sodium cyanide (NaCN). Whole cell currents were recorded using the tight-seal whole-cell voltage clamp technique. Application of NaCN caused an inward whole-cell current. From all tested toxins, which included several indoles, guanidino compounds, polyamines, purines, phenols, DL-homocysteine, orotate and myoinositol, only creatinine (CTN), guanidine (G) and guanidinosuccinic acid (GSA) produced a significant current in control and hypoxic neurons. Current evoked by GSA was significantly increased in the chemical hypoxic condition, and a synergistic effect of GSA and spermine was observed in hypoxic neurons.

Related Compounds

  • Guanidinosuccinic...

Related Articles:

Uraemic guanidino compounds inhibit gamma-aminobutyric acid-evoked whole cell currents in mouse spinal cord neurones.

1999-04-16

[Neurosci. Lett. 265(2) , 83-6, (1999)]

Accumulation of methylguanidine and changes in guanidino compound levels in plasma, urine, and kidneys of furosemide-treated rats.

2008-06-01

[Metab. Clin. Exp. 57(6) , 802-10, (2008)]

Formation of guanidinosuccinic acid, a stable nitric oxide mimic, from argininosuccinic acid and nitric oxide-derived free radicals.

1999-07-01

[Free Radic. Res. 31(1) , 59-65, (1999)]

First indications demonstrating the preventive effects of NZ-419, a novel intrinsic antioxidant, on the initiation and/or progression of chronic renal failure in rats.

2009-07-01

[Biol. Pharm. Bull. 32(7) , 1204-8, (2009)]

Inhibition of arginine synthesis by urea: a mechanism for arginine deficiency in renal failure which leads to increased hydroxyl radical generation.

2003-02-01

[Mol. Cell Biochem. 244(1-2) , 11-5, (2003)]

More Articles...