Chemistry Letters

A convenient synthesis of acetylenic ketones from. BETA.-diketones using. ALPHA.,. ALPHA.-difluoroalkylamines and freeze-dried potassium fluoride.

T Kitazume, N Ishikawa

Index: Kitazume, Tomoya; Ishikawa, Nobuo Chemistry Letters, 1980 , p. 1327 - 1328

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Citation Number: 12

Abstract

α, α-Difluoroalkylamines, such as 1-diethylamino-2-chloro-1, 1, 2-trifluoroethane (1) and 1- diethylamino-1, 1, 2, 3, 3, 3-hexafluoropropane (2), were found to be useful dehydrating agents for the synthesis of acetylenic ketones from β-diketones in the presence of freeze- dried potassium fluoride in acetonitrile.

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