Eksperimental'naia i klinicheskaia farmakologiia 2012-01-01

[Experimental justification of approaches to pharmacological correction of delayed disorders caused by acute ethylene glycol poisoning].

M M Liubishin, K V Sivak, T N Savateeva-Liubimova

Index: Eksp. Klin. Farmakol. 75(11) , 31-4, (2012)

Full Text: HTML

Abstract

The development of delayed disorders caused by acute ethylene glycol poisoning has been studied in experiments on male rats. These disorders include chronic renal failure and secondary combined immunodeficiency status of the "circulus vitiosus" type. Urgent pharmacological correction was shown to be necessary shortly after the poisoning. The experimental therapy (administration of immunomodulators with various mechanisms of action in addition to conventional antidote treatment with ethanol) resulted in the restoration of nonspecific resistance and both cellular and humoral immunity. Reduction of the urinary system damage after the administration of immunomodulators was observed. The results demonstrated the importance of multiagent immunotherapy for the correction of delayed effects of acute ethylene glycol poisoning.

Related Compounds

  • SodiuM bicarbonat...
  • Ethylene glycol
  • 2-(9-Oxoacridin-10...

Related Articles:

Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.

2015-01-01

[Drug Des. Devel. Ther. 9 , 1555-84, (2015)]

Calcium entry via connexin hemichannels in lens epithelium.

2015-03-01

[Exp. Eye Res. 132 , 52-8, (2015)]

H4 histamine receptors inhibit steroidogenesis and proliferation in Leydig cells.

2014-12-01

[J. Endocrinol. 223(3) , 241-53, (2014)]

An integrated biological approach to guide the development of metal-chelating inhibitors of influenza virus PA endonuclease.

2015-02-01

[Mol. Pharmacol. 87(2) , 323-37, (2015)]

Transcriptome analysis of Wnt3a-treated triple-negative breast cancer cells.

2015-01-01

[PLoS ONE 10(4) , e0122333, (2015)]

More Articles...