Direct Amidation of Alcohols with N??Substituted Formamides under Transition??Metal??Free Conditions

…, Y Hu, S Zhang, Z Zha, Z Wang

Index: Xu, Kun; Hu, Yanbin; Zhang, Sheng; Zha, Zhenggen; Wang, Zhiyong Chemistry - A European Journal, 2012 , vol. 18, # 32 p. 9793 - 9797

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Citation Number: 94

Abstract

Amides are one of the most important units in a wide range of natural and designed compounds with biologically relevant properties.[1] The importance of the amide motif necessitates the development of efficient methods for their preparation. Recently, Li etal. described an elegant procedure for the direct amidation of simple aldehydes with amines.[2] With the aim to construct an amide bond in a clean atom-economical manner, several ...

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