Synthesis of primary amines by one-pot reductive amination of aldehydes

…, H Ammar, S Abid, RE Gharbi, M Delmas

Index: Ayedi, Mohamed Ali; Le Bigot, Yves; Ammar, Houcine; Abid, Souhir; Gharbi, Rachid El; Delmas, Michel Synthetic Communications, 2013 , vol. 43, # 16 p. 2127 - 2133

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Citation Number: 6

Abstract

We report here a novel, one-pot, two-step reductive amination of aldehydes for the atom-economical synthesis of primary amines. The amination step has been carried out with hydroxylammonium chloride and does not require the use of a base. In the subsequent reduction step, a metal zinc/hydrochloride acid system has been used. This method is applicable to both aliphatic and aromatic aldehydes. The operational simplicity, the short reaction times, and the mild ...

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