Anticancer Research 1987-01-01

Methylthiopropylamine, a potent inhibitor of spermidine synthase and its antiproliferative effect on human lymphoid leukemia Molt 4B cells.

H Hibasami, M Sakurai, S Maekawa, K Nakashima

Index: Anticancer Res. 7(6) , 1213-6, (1987)

Full Text: HTML

Abstract

The catalytic activity of spermidine synthase isolated from rat ventral prostate was significantly inhibited by methylthiopropylamine (MTPA). Spermine synthase was almost insensitive to this inhibitor. Inhibition of spermidine synthase by MTPA was competitive with respect to a substrate putrescine (Ki, 3.3 = 10(-7) M), but not competitive with another substrate decarboxylated S-adenosylmethionine (dec AdoMet). MTPA inhibited the growth of human lymphoid leukemia Molt 4B cells. The spermidine content in the inhibitor-treated cells was dose-dependently depressed, whereas the putrescine content was increased concomitantly. In these spermidine depleted and growth retarded Molt 4B cells, the synthesis of protein, but not of DNA or RNA, was found to be significantly diminished.

Related Compounds

  • 3-(methylthio)prop...

Related Articles:

High-precision position-specific isotope analysis of 13C/12C in leucine and methionine analogues.

2003-10-15

[Anal. Chem. 75(20) , 5495-503, (2003)]

Time-resolved chemically induced dynamic nuclear polarization studies of structure and reactivity of methionine radical cations in aqueous solution as a function of pH.

2005-11-17

[J. Phys. Chem. A 109(45) , 10459-66, (2005)]

Adducts of Rh2[MTPA]4 with some phosphine chalcogenides: nature of binding and ligand exchange.

2004-07-01

[Magn. Reson. Chem. 42(7) , 600-4, (2004)]

Inhibition by polyamines of methylthiopropylamine-induced ornithine decarboxylase in human lymphoid leukemia Molt 4B cells.

1989-11-01

[Biochem. Pharmacol. 38(21) , 3673-6, (1989)]

Photodissociation of S atom containing amino acid chromophores.

2007-08-14

[J. Chem. Phys. 127(6) , 064308, (2007)]

More Articles...