Applied and Environmental Microbiology 1982-03-01

Biosynthesis of radiolabeled verruculogen by Penicillium simplicissimum.

J B Day, P G Mantle

Index: Appl. Environ. Microbiol. 43(3) , 514-6, (1982)

Full Text: HTML

Abstract

In surface culture of Penicillium simplicissimum, verruculogen was shown to be biosynthesized from the intact carbon skeletons of tryptophan and proline, isoprenoid derivatives of mevalonic acid, and a methyl group donated by methionine. Selected radiolabeled precursors (1 mCi) pulse-fed at the optimum stage of fermentation yielded verruculogen (specific activity, 5.89 X 10(2) microCi mmol-1) labeled in the prolyl and isoprenyl regions of the molecule and suitable for metabolic studies.

Related Compounds

  • Verruculogen

Related Articles:

Verruculogen production in airborne and clinical isolates of Aspergillus fumigatus Fres.

2005-12-01

[Acta. Pharm. 55(4) , 357-64, (2005)]

Actions of tremorgenic fungal toxins on neurotransmitter release.

1980-01-01

[J. Neurochem. 34(1) , 33-42, (1980)]

A comparative study of sheep and pigs given the tremorgenic mycotoxins verruculogen and penitrem A.

1982-09-01

[Res. Vet. Sci. 33(2) , 183-7, (1982)]

Actions of a tremorgenic mycotoxin on amino acid transmitter release in vivo.

1982-09-01

[Biochem. Pharmacol. 31(17) , 2807-10, (1982)]

FtmOx1, a non-heme Fe(II) and alpha-ketoglutarate-dependent dioxygenase, catalyses the endoperoxide formation of verruculogen in Aspergillus fumigatus.

2009-10-07

[Org. Biomol. Chem. 7(19) , 4082-7, (2009)]

More Articles...