Fitoterapia 2010-09-01

Effects of scoparone on dopamine release in PC12 cells.

Yoo Jung Yang, Hak Ju Lee, Byung Koo Lee, Sung Cil Lim, Chong Kil Lee, Myung Koo Lee

Index: Fitoterapia 81(6) , 497-502, (2010)

Full Text: HTML

Abstract

The effects of scoparone on dopamine release in PC12 cells were investigated. Scoparone at 50-200 microM increased dopamine release into the culture medium. However, the released levels of dopamine by scoparone were not altered in the absence of extracellular Ca(2+) and by adenylyl cyclase inhibitor MDL-12,330A. Scoparone increased phosphorylation of PKA, CaMK II and synapsin I. Scoparone also enhanced K(+)-induced levels of dopamine release by CaMK II phosphorylation. These results suggest that scoparone increases dopamine release by synapsin I phosphorylation via activation of PKA and CaMK II, which are mediated by cyclic AMP levels and Ca(2+) influx.Copyright (c) 2010 Elsevier B.V. All rights reserved.

Related Compounds

  • MDL 12330A hydro...
  • Scoparone

Related Articles:

Apparent PKA activity responds to intermittent hypoxia in bone cells: a redox pathway?

2010-07-01

[Am. J. Physiol. Heart Circ. Physiol. 299 , 225-35, (2010)]

Stimulating effects of dopamine on chloride transport across the rat caudal epididymal epithelium in culture.

2009-01-01

[Biol. Reprod. 80(1) , 13-23, (2009)]

Dopamine D1 receptors mediate dopamine-induced duodenal epithelial ion transport in rats.

2013-05-01

[Transl. Res. 161(6) , 486-94, (2013)]

Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster.

2008-11-01

[Eur. J. Neurosci. 28(10) , 1956-66, (2008)]

Cellular mechanism underlying formaldehyde-stimulated Cl- secretion in rat airway epithelium.

2013-01-01

[PLoS ONE 8(1) , e54494, (2013)]

More Articles...