Bipolar Disorders 2003-12-01

Mood-stabilizers: the archeology of the concept.

Margaret Harris, Summit Chandran, Nabonita Chakraborty, David Healy

Index: Bipolar Disord. 5(6) , 446-52, (2003)

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Abstract

To review the history of 'mood-stabilizing' treatments.We have reviewed primary source data on the origin of the use of current mood-stabilizers.This historical record on the origins of the mood-stabilizers points to a more ambiguous picture as regards pharmacotherapeutic specificity to bipolar disorders than is commonly conceded.This review suggests a need for alternative formulations of the concept of a mood-stabilizer. An alternative to the currently dominant paradigm is that these agents have treatment effects, which need to be matched more precisely with patients' constitutional types in order to optimize outcomes.

Related Compounds

  • Valpromide

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