6-(Alkylamino)-9-alkylpurines. A new class of potential antipsychotic agents

…, RM Bullock, MP Krochmal, EW McLean…

Index: Kelley, James L.; Morris Bullock; Krochmal, Mark P.; McLean, Ed W.; Linn, James A.; Durcan, Micheal J.; Cooper, Barrett R. Journal of Medicinal Chemistry, 1997 , vol. 40, # 20 p. 3207 - 3216

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Citation Number: 27

Abstract

A series of 6-(alkylamino)-9-alkylpurines was synthesized and evaluated for the property of antagonizing the behavioral effects in animals of the dopamine agonist apomorphine. This model for identifying potential antipsychotic agents is based on the hypothesis that agents that antagonize apomorphine-induced aggressive behavior in rats and apomorphine- induced climbing in mice, but that do not block stereotyped behavior, could have an ...