A short synthesis of 3, 6-disubstituted N-2-thienyl/aryl-indoles

HB Borate, SP Sawargave, SR Maujan

Index: Borate, Hanumant B.; Sawargave, Sangmeshwer P.; Maujan, Suleman R. Tetrahedron Letters, 2009 , vol. 50, # 47 p. 6562 - 6566

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Citation Number: 6

Abstract

A short synthetic strategy for 3, 6-disubstituted-N-2-thienyl/aryl-indoles, involving reaction of substituted 2, 4-difluoro/dichloro-styrene epoxide with substituted 2-formylaminothiophenes or substituted N-formylanilines in the presence of a base followed by treatment with an acid, has been developed. The method was applied for the synthesis of a number of indoles with a variety of substituents at 1, 3, and 6 positions of the indole moiety.