Biochemical and Biophysical Research Communications 2002-07-05

The antioxidant activity of phloretin: the disclosure of a new antioxidant pharmacophore in flavonoids.

Bashir M Rezk, Guido R M M Haenen, Wim J F van der Vijgh, Aalt Bast

Index: Biochem. Biophys. Res. Commun. 295(1) , 9-13, (2002)

Full Text: HTML

Abstract

Phloretin is a dihydrochalcone flavonoid that displays a potent antioxidant activity in peroxynitrite scavenging and the inhibition of lipid peroxidation. Comparison with structurally related compounds revealed that the antioxidant pharmacophore of phloretin is 2,6-dihydroxyacetophenone. The potent activity of 2,6-dihydroxyacetophenone is due to stabilisation of its radical via tautomerisation. The antioxidant pharmacophore in the dihydrochalcone phloretin, i.e., the 2,6-dihydroxyacetophenone group, is different from the antioxidant pharmacophores previously reported in flavonoids.(c) 2002 Elsevier Science (USA).

Related Compounds

  • 2,6-Dihydroxyaceto...
  • Phloretin

Related Articles:

Molecular modeling and inhibition of phospholipase A2by polyhydroxy phenolic compounds

2009-01-01

[Eur. J. Med. Chem. 44 , 312-21, (2009)]

Novel squalene-hopene cyclase inhibitors derived from hydroxycoumarins and hydroxyacetophenones.

2004-10-01

[Chem. Pharm. Bull. 52(10) , 1171-4, (2004)]

MALDI mass spectrometry in the solution of some forensic problems.

2004-12-02

[Forensic Sci. Int. 146 Suppl , S83-5, (2004)]

Study of the acute human health effects of intermediates in the synthesis of sodium cromoglycate.

1995-04-01

[Ann. Occup. Hyg. 39(2) , 235-40, (1995)]

Enhanced MALDI-TOF MS analysis of phosphopeptides using an optimized DHAP/DAHC matrix.

2010-01-01

[J. Biomed. Biotechnol. 2010 , 759690, (2010)]

More Articles...