Journal of Combinatorial Chemistry 2010-09-13

Novel isocyanide-based one-pot multicomponent syntheses of tetrahydrobenzo[b][1,4]oxazepine and malonamide derivatives.

Ahmad Shaabani, Hamid Mofakham, Ali Maleki, Fatemeh Hajishaabanha

Index: J. Comb. Chem. 12(5) , 630-2, (2010)

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Abstract

In this work, a novel one-pot multicomponent reaction of 2-aminophenols, Meldrum's acid, and isocyanides leads to the synthesis of tetrahydrobenzo[b][1,4]oxazepine or malonamide derivatives using 1 or 2 equiv of 2-aminophenols, respectively, in good to excellent yields at ambient temperature.

Related Compounds

  • aminophenol
  • Malonamide

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