Nippon rinsho. Japanese journal of clinical medicine 2013-11-01

[Endocrinological aspects of diabetes mellitus in the elderly].

Kiyoshi Hashizume

Index: Nihon Rinsho. 71(11) , 1941-7, (2013)

Full Text: HTML

Abstract

Glucose-mediated energy production in central nervous system(CNS) reduces in the elderly. The reduction is also observed in young patients with diabetes mellitus(DM). Deviated endocrinological function is observed in both the elderly and young patients with DM. The deviation is characterized by mechanism of adaptation to the insufficient energy production in CNS. The decrease of glucose-mediated energy production is accelerated by decrease of the activity of growth hormone-insulin-like growth factor 1 axis and of conversion of thyroxine to triiodothyronine. These decreases are suitable for adaptation to the insufficient CNS activity induced by energy deficiency. Glucagon- and catecholamine-induced increases in plasma glucose level contribute to increase energy production. Parathyroid hormone action is activated in the elderly, which contributes to the inhibition of excess signal transduction in energy-deficient CNS. These deviations are considered as adaptations to the energy deficiency observed in aged patients with DM.

Related Compounds

  • D-(+)-Glucose
  • L-Glucose
  • L-thyroxine
  • Glucagon

Related Articles:

Neuropeptide Y in the noradrenergic neurones induces obesity and inhibits sympathetic tone in mice.

2015-04-01

[Acta Physiol. (Oxf.) 213(4) , 902-19, (2015)]

Targeting glucose uptake with siRNA-based nanomedicine for cancer therapy.

2015-05-01

[Biomaterials 51 , 1-11, (2015)]

Differential expression of efflux pump genes of Mycobacterium tuberculosis in response to varied subinhibitory concentrations of antituberculosis agents.

2015-03-01

[Tuberculosis (Edinb.) 95(2) , 155-61, (2015)]

Diclofenac toxicity in human intestine ex vivo is not related to the formation of intestinal metabolites.

2015-01-01

[Arch. Toxicol. 89(1) , 107-19, (2015)]

Effect of (2)H and (18)O water isotopes in kinesin-1 gliding assay.

2014-01-01

[PeerJ 2 , e284, (2014)]

More Articles...