Critical Reviews in Toxicology 2010-07-01

Genetic toxicology of folpet and captan.

Gail T Arce, Elliot B Gordon, Samuel M Cohen, Pramila Singh

Index: Crit. Rev. Toxicol. 40(6) , 546-74, (2010)

Full Text: HTML

Abstract

Folpet and captan are fungicides whose genotoxicity depends on their chemical reaction with thiols. Multiple mutagenicity tests have been conducted on these compounds due to their positive activity in vitro and their association with gastrointestinal tumors in mice. A review of the collective data shows that these compounds have in vitro mutagenic activity but are not genotoxic in vivo. This dichotomy is primarily due to the rapid degradation of folpet and captan in the presence of thiol-rich matrices typically found in vivo. Genotoxicity has not been found in the duodenum, the mouse tumor target tissue. It is concluded that folpet like captan presents an unlikely risk of genotoxic effects in humans.

Related Compounds

  • captan
  • Folpet

Related Articles:

Determination of pesticides in sunflower seeds by high-performance liquid chromatography coupled with a diode array detector.

2014-01-01

[J. AOAC Int. 97(4) , 1012-20, (2014)]

[Survey of pesticide residues in imported frozen vegetables and fruits (1989.4~2008.3)].

2011-01-01

[Shokuhin Eiseigaku Zasshi 52(2) , 121-9, (2011)]

Toxicokinetics of captan and folpet biomarkers in orally exposed volunteers.

2012-03-01

[J. Appl. Toxicol. 32(3) , 194-201, (2012)]

Air pollutants formed in thermal decomposition of folpet fungicide under oxidative conditions.

2011-01-15

[Environ. Sci. Technol. 45(2) , 554-60, (2011)]

Effects of captan on Apis mellifera brood development under field conditions in California almond orchards.

2009-02-01

[J. Econ. Entomol. 102(1) , 20-9, (2009)]

More Articles...