The Journal of Organic Chemistry

A convenient, mild method for oxidative cleavage of alkenes with Jones reagent/osmium tetraoxide

JR Henry, SM Weinreb

Index: Henry, James R.; Weinreb, Steven M. Journal of Organic Chemistry, 1993 , vol. 58, # 17 p. 4745

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Citation Number: 46

Abstract

Oxidative scission of alkenes is a widely used method for preparation of carboxylic acids and ketones.'The most common reagents for this transformation include ozone, potassium permanganate, and ruthenium tetraoxide. In addition, several methods exist involving initial oxidation of an alkene to al, 2-dioP3 or epoxide? followed by CC bond cleavage to the acid and/or ketone. During the course of a project in alkaloid total synthesis, we required a ...

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