Synthesis of pentabromopseudilin and other arylpyrrole derivatives via Heck arylations

CS Schwalm, IBD de Castro, J Ferrari, FL de Oliveira…

Index: Schwalm, Cristiane S.; De Castro, Ilton B.D.; Ferrari, Jailton; De Oliveira, Fabio L.; Aparicio, Ricardo; Correia, Carlos Roque D. Tetrahedron Letters, 2012 , vol. 53, # 13 p. 1660 - 1663

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Citation Number: 16

Abstract

Pentrabromopseudilin and other 2 and 3-arylpyrrole derivatives were synthesized through the Heck–Matsuda reaction involving endocyclic enecarbamates and N-protected 3- pyrrolines, respectively. The overall processes permitted an easy and efficient access to these structural motifs present in several bioactive compounds. Attempts to synthesize the compound isopentabromopseudilin led to a tribromo aryl maleimide. We hypothesize that ...