Irreversible Enzyme Inhibitors. CVII. 1 Proteolytic Enzymes. II. 2 Bulk Tolerance within Chymotrypsin-Inhibitor Complexes

BR Baker, JA Hurlbut

Index: Baker,B.R.; Hurlbut,J.A. Journal of Medicinal Chemistry, 1967 , vol. 10, p. 1129 - 1133

Full Text: HTML

Citation Number: 8

Abstract

Fifty-eight compounds related to phenoxyacetone and phenosyacetamide have been measured as inhibitors of a-chymotrypsin. Substitution of 3-chloro, 2, 3-dichloro, or 3, 4- dichloro groups on phenoxyacetone increased hinding of phenoxyacetone 11-23-fold; bulky groups such as methyl or ethyl were detrimental to binding, brit, flat hydrocarbon substituents such as o-phenyl or benzo were beneficial to binding. Ariilides and E- ...