Organic Letters 2010-01-15

Stereoselective aldol reaction of glutarimides using pseudo C(2) symmetry.

Yohsuke Watanabe, Takashi Yamazaki, Toshio Kubota

Index: Org. Lett. 12(2) , 268-71, (2010)

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Abstract

The boron aldol reaction of beta-substituted glutaric imides bearing an oxazolidinone-based auxiliary proceeds with excellent diastereoselectivity; switching the tertiary amine employed between i-Pr(2)EtN or Et(3)N affords enantiomeric lactone product.

Related Compounds

  • Glutarimide

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