Chemical & Pharmaceutical Bulletin 2010-11-01

Synthesis and antiviral activities of synthetic glutarimide derivatives.

Xing-yue Ji, Zhao-jin Zhong, Si-tu Xue, Shuai Meng, Wei-ying He, Rong-mei Gao, Yu-huan Li, Zhuo-rong Li

Index: Chem. Pharm. Bull. 58(11) , 1436-41, (2010)

Full Text: HTML

Abstract

A series of novel glutarimide compounds were synthesized and their antiviral activities were evaluated. The compounds displaying the strongest antiviral activities included 5, 6f, 7e and 9 against coxsackievirus B3 (Cox B3), 10 and 6f against influenza virus A (influenza A) and 7a against herpes simplex virus 2 (HSV-2). However, most of the synthetic glutarimides showed comparatively much weaker activity against influenza A, Cox B3 and HSV-2 than the natural glutarimide compounds tested. Based on the results, it seemed likely that a conjugated system at the β-substituted moiety provides stronger antiviral activity.

Related Compounds

  • Glutarimide

Related Articles:

Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.

2014-12-16

[Biochemistry 53(49) , 7854-65, (2014)]

Iso-migrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds.

2005-08-31

[J. Am. Chem. Soc. 127(34) , 11930-1, (2005)]

Enantiomerization mechanism of thalidomide and the role of water and hydroxide ions.

2012-11-05

[Chemistry 18(45) , 14305-13, (2012)]

Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.

2008-11-15

[Bioorg. Med. Chem. Lett. 18(22) , 5951-4, (2008)]

Inhibition of macrophage activation and suppression of graft rejection by DTCM-glutarimide, a novel piperidine derived from the antibiotic 9-methylstreptimidone.

2011-09-01

[Inflamm. Res. 60(9) , 879-88, (2011)]

More Articles...