Tetrahedron Letters

An expedient synthesis of 6-arylpiperidine-2, 4-diones by chain-extension of β-aryl-β-aminoacids

N Leflemme, P Dallemagne, S Rault

Index: Leflemme, Nicolas; Dallemagne, Patrick; Rault, Sylvain Tetrahedron Letters, 2001 , vol. 42, # 51 p. 8997 - 8999

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Citation Number: 19

Abstract

The synthesis of novel 6-arylpiperidine-2, 4-diones is described in five steps starting from β- aryl-β-aminoacids via the chain extension of the latter into δ-aryl-δ-amino-β-ketoacids. The chemical pathway involves an acylation of Meldrum's acid and yields useful building blocks for heterocyclic chemistry.

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