Mechanism??Inspired Engineering of Phenylalanine Aminomutase for Enhanced β??Regioselective Asymmetric Amination of Cinnamates

B Wu, W Szymański, GG Wybenga…

Index: Wu, Bian; Szymanski, Wiktor; Wybenga, Gjalt G.; Heberling, Matthew M.; Bartsch, Sebastian; Dewildeman, Stefaan; Poelarends, Gerrit J.; Feringa, Ben L.; Dijkstra, Bauke W.; Janssen, Dick B. Angewandte Chemie - International Edition, 2012 , vol. 51, # 2 p. 482 - 486

Full Text: HTML

Citation Number: 23

Abstract

In the last decade, enormous progress has been made in the synthesis of optically pure β- amino acids, which occur as components of numerous bioactive compounds.[1] Although biocatalytic routes have been explored, they tend to use kinetic resolutions, implying a maximum yield of 50%.[2] Only a few enzymes, including aminotransferases [3] and aminomutases,[4] have been used in asymmetric synthesis of this class of compounds. ...

Related Articles:

Chemoenzymatic synthesis of both enantiomers of 3-hydroxy-and 3-amino-3-phenylpropanoic acid

[Varga, Annamaria; Zaharia, Valentin; Nogradi, Mihaly; Poppe, Laszlo Tetrahedron Asymmetry, 2013 , vol. 24, # 21-22 p. 1389 - 1394]

Parallel synthesis of homochiral β-amino acids

[Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D. Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566]

Capillary electrophoretic separation of enantiomers of amino acids and amino acid derivatives using crown ether and cyclodextrin

[Pharmazie, , vol. 60, # 3 p. 181 - 185]

Microbial production of optically active β-phenylalanine through stereoselective degradation of racemic β-phenylalanine

[Bioscience, Biotechnology and Biochemistry, , vol. 70, # 8 p. 1941 - 1946]

Astins K–P, six new chlorinated cyclopentapeptides from Aster tataricus

[Tetrahedron, , vol. 69, # 37 p. 7964 - 7969]

More Articles...