Synthesis and in vitro Evaluation of West Nile Virus Protease Inhibitors Based on the 1, 3, 4, 5??Tetrasubstituted 1H??Pyrrol??2 (5H)??one Scaffold

Y Gao, S Samanta, T Cui, Y Lam

Index: Gao, Yaojun; Samanta, Sanjay; Cui, Taian; Lam, Yulin ChemMedChem, 2013 , vol. 8, # 9 p. 1554 - 1560

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Citation Number: 9

Abstract

Abstract West Nile virus (WNV), a member of the Flaviviridae family, is a mosquito-borne pathogen that causes a large number of human infections each year. There are currently no vaccines or antiviral therapies available for human use against WNV. Therefore, efforts to develop new chemotherapeutics against this virus are highly desired. In this study, a WNV NS2B–NS3 protease inhibitor with a 1, 3, 4, 5-tetrasubstituted 1H-pyrrol-2 (5H)-one ...