Scope and Limitation for FeSO 4-Mediated Direct Arylation of Heteroarenes with Arylboronic Acids and Its Synthetic Applications

K Komeyama, Y Nagao, M Abe, K Takaki

Index: Komeyama, Kimihiro; Nagao, Yuya; Abe, Manabu; Takaki, Ken Bulletin of the Chemical Society of Japan, 2014 , vol. 87, # 2 p. 301 - 313

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Citation Number: 5

Abstract

FeSO 4-mediated direct arylation of heteroarenes with arylboronic acids in the presence of K 2 S 2 O 8 has been developed. A slow addition of an aqueous solution of an iron complex was crucial in the arylation. Scope and limitation of the heteroarenes and arylboronic acids are discussed. Furthermore, the direct arylation was applied to the formal total synthesis botryllazine B and sodium channel inhibitor.

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