The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by β-oxocarboxylic acids

B Banerji, A Conejo-Garcia, LA McNeill…

Index: Banerji, Biswadip; Conejo-Garcia, Ana; McNeill, Luke A.; McDonough, Michael A.; Buck, Matthew R. G.; Hewitson, Kirsty S.; Oldham, Neil J.; Schofield, Christopher J. Chemical Communications, 2005 , # 43 p. 5438 - 5440

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Citation Number: 19

Abstract

The hypoxic response can be induced in cells by reagents including cobaltous ions and non-specific iron chelators (eg desferrioxamine); 2 these reagents may effect their activity by competing with iron (cobaltous ions) or depriving the HIF hydroxylases of ferrous iron (desferrioxamine), though other mechanisms are possible. Prior to the identification of the role of prolyl-hydroxylation in the hypoxic response, procollagen prolyl-hydroxylase had been ...